Purified anti-IRF-3

Cat no: 648701

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

IRF-3 is a member of the interferon regulatory transcription factor (IRF) family. It mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity. DsRNA generated during the course of a viral infection leads to IRF-3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB protein binding to dsRNA-activated factor 1, a complex which activates the transcription of genes under control of ISRE. The phosphorylated IRF-3 is under negative regulation by ubiquitin-mediated degradation. Recent research indicates that it plays a critical role in stimulated TLR-mediated IL-27 P28 gene expression.

Catalogue number:	648701
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	SL-12
Gene:	3661
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 microg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Recombinant GST-IRF-3(56-427) protein
Isotype:	Mouse IgG1
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Interferon regulatory factor-3, IRF3