Purified anti-LAT

Cat no: 641101

Supplier: BioLegend

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Description
Additional Information

LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcepsilonRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.

Catalogue number:	641101
Reactivities:	Human, Mouse
Hosts:	Mouse
Applications:	Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	11B.12
Gene:	27040
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store at 4C
Concentration:	0.5 mg/ml
Antigen:	GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain.
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Linker for activation of T cells