Purified anti-mouse Aiolos

Cat no: 653202

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

Aiolos, an Ikaros family member, is also known as Izkf3. It has a molecular weight of 58 kD and shows 70% homology to the Ikaros isoform, Ik-1, particularly in the DNA binding and C-terminal domains. Aiolos can form a heteromer with Ikaros or exist as a homodimer. The homomeric complex is a potent transcriptional activator. Unlike Ikaros, Aiolos is expressed in late fetal thymus and adult lymphoid organs. Among the adult hematopoietic progenitors, Aiolos is expressed at low levels in mulitpotent but not in pluripotent stem cells. When these multipotent progenitors become more restricted to T and B lymphoid pathways there is an upregulation in Aiolos expression. The highest expression of Aiolos is detected in the spleen (especially in B-cells) followed by thymus and bone marrow, and cannot be detected in the non-lymphoid organs. Aiolos plays an important role in lymphocyte proliferation and differentiation.

Catalogue number:	653202
Reactivities:	Mouse
Hosts:	Mouse
Applications:	Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Size:	100 microg
Clone:	8B2
Gene:	22780
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 microg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	N-terminal half of mouse Aiolos fused to GST
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Ikzf3, Zfpn1a3, Znfn1a3

See Full Product Listings >

Purified anti-mouse Aiolos

Cat no: 653202

About Biosave

Product Categories

Information