Purified anti-mouse CD103

Cat no: 121402

Supplier: BioLegend

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CD103 is a type I transmembrane glycoprotein known as alphaE integrin or Integrin alphaIEL chain. It belongs to integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-beta stimulation. In association with integrin beta7, CD103 is expressed as alphaE/beta7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Catalogue number:	121402
Reactivities:	Mouse
Hosts:	Hamster
Applications:	Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size:	200 microg
Clone:	2E7
Gene:	16407
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Mouse intestinal intraepithelial lymphocytes
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Integrin alphaIEL chain, Integrin alphaE chain, alphaE integrin

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Purified anti-mouse CD103

Cat no: 121402

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