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Purified anti-mouse CD123

Purified anti-mouse CD123

Cat no: 106002

Supplier: BioLegend
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CD123 is a 70 kD alpha chain subunit of the IL-3 receptor (IL-3R alpha). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common beta chain (CDw131) or the IL-3R beta chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the alpha subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R beta subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
Catalogue number: 106002
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 500 microg
Clone: 5B11
Gene: 16188
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: CTLL cells transfected with the mouse IL-3Ralpha chain
Isotype: Rat IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: IL-3 Receptor alpha chain, IL-3Ralpha
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