Purified anti-mouse CD152

Cat no: 106202

Supplier: BioLegend

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Description
Additional Information

CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation. The 9H10 antibody can enhance T cell co-stimulation by blocking CTLA-4 interactions with the B7 co-receptors, favoring CD28 interactions.

Catalogue number:	106202
Reactivities:	Mouse
Hosts:	Hamster
Applications:	ELISA, Flow Cytometry
Size:	500 microg
Clone:	9H10
Gene:	12477
Dilutions:	Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Mouse CTLA-4-human IgG1 fusion protein
Isotype:	Syrian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Cytotoxic T Lymphocyte-Associated Antigen-4, CTLA-4, Ly-56