Purified anti-mouse CD172a (SIRPalpha)

Cat no: 144001

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

CD172a, also known as SIRPalpha, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPalpha ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.

Catalogue number:	144001
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Size:	50 microg
Clone:	P84
Gene:	19261
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Mouse brain membrane protein
Isotype:	Rat IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	SHPS-1, BIT, P84, PTPNS1