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Purified anti-mouse CD49b

Purified anti-mouse CD49b

Cat no: 103501

Supplier: BioLegend
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CD49b is a 150 kD glycoprotein, also known as alpha2 integrin, VLA-2 alpha chain, Integrin alpha2 chain, and HMalpha2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin beta1 subunit), CD49b forms the VLA-2 (integrin alpha2beta1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. The HMalpha2 antibody has been shown to be useful for partially blocking CD49b mediated interactions with collagen. Additionally, this antibody blocks staining of splenic NK cells by the monoclonal antibody DX5.
Catalogue number: 103501
Reactivities: Mouse
Hosts: Hamster
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 50 microg
Clone: HMa2
Gene: 16398
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Mouse colon carcinoma cell line Colon26
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alpha2 integrin, VLA-2 alpha chain, Integrin alpha2, HMa2
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