Purified anti-mouse CLEC9A (DNGR1)

Cat no: 143501

Supplier: BioLegend

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Description
Additional Information

CLEC9A, also known as DNGR1, is a 264 amino acid (aa) type II transmembrane glycoprotein which belongs to the C-type lectin superfamily. It contains a 208 aa extracellular region with a single carbohydrate recognition domain (CRD) and a cytoplasmic segment (35 aa) bearing an immunoreceptor tyrosine-based activation motif (ITAM). In mice, CLEC9A is strictly expressed on CD8a-positive dendritic cells and plasmacytoid dendritic cells. It recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.

Catalogue number:	143501
Reactivities:	Mouse
Hosts:	Rat
Applications:	ELISA, Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	7H11
Gene:	232414
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Isotype:	Rat IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	DNGR-1, C-type lectin domain family 9 member A