Purified anti-mouse FcepsilonRIalpha

Cat no: 134302

Supplier: BioLegend

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Description
Additional Information

FcepsilonRIalpha is a transmembrane protein belonging to the Ig superfamily. FcepsilonRIalpha forms a tetrameric complex with one beta and two gamma-subunits. The FcepsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcepsilonRIalpha, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcepsilonRIalpha subunit.

Catalogue number:	134302
Reactivities:	Mouse
Applications:	Flow Cytometry, Immunohistochemistry
Size:	500 microg
Clone:	MAR-1
Gene:	2205
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	FceRIa, FceRI-alpha, high affinity IgE receptor