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Purified anti-mouse GARP (LRRC32)

Purified anti-mouse GARP (LRRC32)

Cat no: 142901

Supplier: BioLegend
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Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing protein 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs. It serves as a receptor for latent TGF-beta. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-beta or to capture TGF-beta from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
Catalogue number: 142901
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 25 microg
Clone: F011-5
Gene: 434215
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Mouse GARP (extracellular domain)
Isotype: Rat IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: LRRC32, Garpin, Glycoprotein A repetitions predominant
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