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Purified anti-mouse/human PNAd

Purified anti-mouse/human PNAd

Cat no: 120802

Supplier: BioLegend
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MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1,3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with mouse, human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo.
Catalogue number: 120802
Reactivities: Human, Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500 microg
Clone: MECA-79
Dilutions: For immunohistochemical staining, the suggested use of this reagent is ? 10 microg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Mouse lymph node stromal cells
Isotype: Rat IgM, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Peripheral Node Addressin, MECA-79
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