Purified anti-mouse IFNAR-1

Cat no: 127301

Supplier: BioLegend

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Description
Additional Information

IFNAR-1, the type I IFN receptor subunit 1, is coexpressed with IFNAR-2 on nearly all cells and make up the heterodimeric receptor complex that binds to all type I IFNs (IFN-alpha/beta). Type I IFNs are a group of structurally and functionally related cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor, and autoimmune responses. Ligand binding to the IFN-alpha/beta receptor complex leads to the tyrosine phosphorylation and activation of IFNAR-1-associated Tyk2 and IFNAR-2-associated Jak1 signal transductions.

Catalogue number:	127301
Reactivities:	Mouse
Hosts:	Mouse
Applications:	ELISA, Flow Cytometry, Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	MAR1-5A3
Gene:	15975
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Plasmid DNA encoding murine IFNAR1 extracellular domain
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	IFNAR1, IFN-alphaR1, IFN-alpha/beta Receptor Subunit 1