Purified anti-mouse IL-22

IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRgammadelta T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rbeta. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and karatinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and crohn’s disease. Moreover, it plays a critical role in mucosal immunity and wound healing process.

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SPECIFICATIONS

Catalog Number

516401

Size

100 microg

Hosts

Goat

Reactivities

Mouse

Clone

Poly5164

Antigen

Mouse IL-22, amino acids Leu34-Val179 (Accession# NM_016971) was expressed in E. coli.

Isotype

Goat Ig

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA capture antibody, a concentration range of 0.5-2 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance. To obtain a linear standard curve, serial dilutions of IL-22 recombinant protein ranging from 250-3.9 pg/ml are recommended.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C. Do not freeze.

Alternative Names

IL22

Regulatory Status

RUO