Purified anti-mouse IL-22

Cat no: 516401

Supplier: BioLegend

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IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRgammadelta T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rbeta. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and karatinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and crohn’s disease. Moreover, it plays a critical role in mucosal immunity and wound healing process.

Catalogue number:	516401
Reactivities:	Mouse
Hosts:	Goat
Size:	100 microg
Clone:	Poly5164
Dilutions:	Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA capture antibody, a concentration range of 0.5-2 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance. To obtain a linear standard curve, serial dilutions of IL-22 recombinant protein ranging from 250-3.9 pg/ml are recommended.
Storage buffer:	The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration:	0.5 mg/ml
Antigen:	Mouse IL-22, amino acids Leu34-Val179 (Accession# NM_016971) was expressed in E. coli.
Isotype:	Goat Ig
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	IL22

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Purified anti-mouse IL-22

Cat no: 516401

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