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Purified anti-mouse IL-23 (p19)

Purified anti-mouse IL-23 (p19)

Cat no: 513801

Supplier: BioLegend
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Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12.IL-23 is secreted by activated macrophages and dendritic cells.Human and mouse p19 share 70% aa sequence identity. The functional IL-23 receptor complex consists of two receptor subunits, a beta1 subunit shared with the IL-12 receptor (IL-12R beta1) and a beta2-like subunit with STAT4 binding domain, termed the IL-23-specific receptor subunit (IL-23R).IL-23 has been shown to enhance IFN-gamma production by memory T cells.Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17.IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections.
Catalogue number: 513801
Reactivities: Mouse
Hosts: Mouse
Applications: Immunofluorescence
Size: 50 microg
Clone: MMp19B2
Gene: 83430
Dilutions: Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA capture antibody, a concentration range of 2-6.0 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of IL-23 recombinant protein ranging from 2000 to 8 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Mouse p19 C-terminal peptide
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-23 p19
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