Purified anti-mouse Notch 3

Cat no: 130502

Supplier: BioLegend

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Description
Additional Information

The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.

Catalogue number:	130502
Reactivities:	Mouse
Hosts:	Hamster
Applications:	Flow Cytometry, Immunohistochemistry
Size:	500 microg
Clone:	HMN3-133
Gene:	18131
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Notch 3-Fc fusion protein
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4C
Alternative names:	Neurogenic locus notch homolog protein 3, Notch-3, Notch3, CADASIL, CASIL