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Purified anti-mouse/rat CD49e

Purified anti-mouse/rat CD49e

Cat no: 103902

Supplier: BioLegend
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CD49e is a 135 kD protein, also known as alpha5 integrin or VLA-5 alpha chain. It is a member of the integrin family, expressed on thymocytes, splenic B cells, activated T cells, and mast cells. CD49e associates with CD29 (integrin beta1 chain) to form the fibronectin receptor (VLA-5). CD49e plays a critical role in both adhesion and T cell costimulation. The primary ligand for CD49e/CD29 (VLA-5) is fibronectin. The HMalpha5-1 antibody has been shown to partially block CD49e mediated interactions. It has also been observed that plate-bound HMalpha5-1 antibody enhances IgE mediated degranulation and that in vivo injection of HMalpha5-1 antibody, in combination with anti-CD49d and anti-CD61 antibodies, blocks passive cutaneous anaphylaxis.
Catalogue number: 103902
Reactivities: Mouse, Rat
Hosts: Hamster
Applications: Flow Cytometry, Immunoprecipitation
Size: 500 microg
Clone: HMalpha5-1
Gene: 16402
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Affinity-purified mouse VLA-5 protein (alpha5beta1, CD49e/CD29)
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alpha5 integrin, VLA-5 alpha chain, Integrin alpha5
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