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Purified anti-mouse VEGFR-3 (FLT-4)

Purified anti-mouse VEGFR-3 (FLT-4)

Cat no: 140901


Supplier: BioLegend
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VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.
Catalogue number: 140901
Reactivities: Mouse
Hosts: Rat
Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50 microg
Clone: AFL4
Gene: 14257
Dilutions: Each lot of this antibody is quality control tested by immunohistochemical staining of mouse frozen tissue sections.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: VEGFR-3-Fc fusion protein
Isotype: Rat IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Vascular endothelial growth factor receptor 3, FLT-4, Fms-like tyrosine kinase 4
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