Purified anti-MyD88

MyD88, originally isolated as myeloid differentiation primary response gene, is expressed in a variety of tissues. MyD88 serves as a cytoplasmic adaptor protein involved in the signaling of TLR and IL-1R family members. It associates with and recruits IRAK to IL-1R complex in response to IL-1. This pathway leads to activation of NF-kB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 deficient mice lack a response to LPS (a bacterial product) which employs toll like receptors 2 and 4 (TLR2 and TLR4) as signaling receptors.

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SPECIFICATIONS

Catalog Number

648901

Size

25 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Clone

Poly6489

Antigen

Synthetic peptide (c-terminus)

Gene Id

4615

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5-2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at -20C.

Alternative Names

Myeloid differentiation primary response gene 88

Regulatory Status

RUO