Purified anti-MyD88

Cat no: 648902

Supplier: BioLegend

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Description
Additional Information

MyD88, originally isolated as myeloid differentiation primary response gene, is expressed in a variety of tissues. MyD88 serves as a cytoplasmic adaptor protein involved in the signaling of TLR and IL-1R family members. It associates with and recruits IRAK to IL-1R complex in response to IL-1. This pathway leads to activation of NF-kB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 deficient mice lack a response to LPS (a bacterial product) which employs toll like receptors 2 and 4 (TLR2 and TLR4) as signaling receptors.

Catalogue number:	648902
Reactivities:	Human, Mouse
Hosts:	Rabbit
Applications:	Western Blot
Size:	100 microl
Clone:	Poly6489
Gene:	4615
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5-2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at -20C.
Antigen:	Synthetic peptide (c-terminus)
Isotype:	Rabbit Polyclonal
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	-20 C
Alternative names:	Myeloid differentiation primary response gene 88