Purified anti-NBS1

NBS1 (Nijmegen breakage syndrome 1, p95 protein of the MRE11/RAD50 complex) is a 95 kD nuclear protein that contains a FHA domain and BRCT domain. NBS1 is involved in DNA double-strand break repair, and DNA damage-induced checkpoint activation. NBS1 mutations are associated with Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. This protein is activated by irradiation, upregulated by c-Myc, and modified by phosphorylation. NBS1 is a component of the double-strand break repair complex consisting of DNL IV/XRCC4, Ku, MRE11, and RAD50. NBS1 has also been shown to associate with FANCD2. The Poly6138 antibody recognizes the C-terminal region of human and mouse NBS1 and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

613801

Size

50 microl

Applications

IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Clone

Poly6138

Antigen

Recombinant (partial), C-terminal

Gene Id

4683

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Nijmegen breakage syndrome 1, p95 protein of the MRE11/RAD50 complex

Regulatory Status

RUO