Purified anti-Nhedc2 (NHA2)

The sodium-proton exchangers (NHE) antiporters of the CPA1 family, catalyze Na+ and H+ exchange. NHE activity is also involved in other cellular events such as cell migration, adhesion and proliferation in response to growth factors. Nhedc2 is a novel member of the CPA family and is the first mitochondrial NHA characterized to date. It is also unique in that it is the first eukaryotic and tissue-specific CPA2 characterized to date. Nhedc2 is localized to the mitochondria, where it mediates Na+-dependent exchanges in mitochondrial PH and Na+ acetate induced mitochondrial passive swelling. It is strongly upregulated during RANKL-induced osteoclast differentiation in vivo and in vitro. RNA silencing of this gene reduces osteoclast differentiation and resorption, suggesting that it plays a key role(s) in normal osteoclast differentiation and function.

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SPECIFICATIONS

Catalog Number

648501

Size

25 microl

Applications

IF, WB

Hosts

Rabbit

Reactivities

Mouse

Clone

Poly6485

Antigen

Synthetic peptide

Gene Id

97086

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 microl in 5 ml blocking buffer (0.2 microg/ml). It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20C.

Alternative Names

NHA2, NHE10, nha-o, Mitochondrial sodium/hydrogen exchanger NHA2

Regulatory Status

RUO