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Purified anti-Nhedc2 (NHA2)

Purified anti-Nhedc2 (NHA2)

Cat no: 648501

Supplier: BioLegend
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The sodium-proton exchangers (NHE) antiporters of the CPA1 family, catalyze Na+ and H+ exchange. NHE activity is also involved in other cellular events such as cell migration, adhesion and proliferation in response to growth factors. Nhedc2 is a novel member of the CPA family and is the first mitochondrial NHA characterized to date. It is also unique in that it is the first eukaryotic and tissue-specific CPA2 characterized to date. Nhedc2 is localized to the mitochondria, where it mediates Na+-dependent exchanges in mitochondrial PH and Na+ acetate induced mitochondrial passive swelling. It is strongly upregulated during RANKL-induced osteoclast differentiation in vivo and in vitro. RNA silencing of this gene reduces osteoclast differentiation and resorption, suggesting that it plays a key role(s) in normal osteoclast differentiation and function.
Catalogue number: 648501
Reactivities: Mouse
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 25 microl
Clone: Poly6485
Gene: 97086
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 microl in 5 ml blocking buffer (0.2 microg/ml). It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20C.
Antigen: Synthetic peptide
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: NHA2, NHE10, nha-o, Mitochondrial sodium/hydrogen exchanger NHA2
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