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Purified anti-Nod2

Purified anti-Nod2

Cat no: 625801

Supplier: BioLegend
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Nod2, also known as caspase recruitment domain-containing protein 15, CARD15, and inflammatory bowel disease protein 1, is a monocyte-specific cytoplasmic protein containing two N-terminal caspase recruitment domains (CARD domains), and multiple leucine-rich repeats with a predicted molecular weight 115 kD. Alternative initiation produces two isoforms of Nod2. Nod2 is thought to confer responsiveness to intracellular bacterial lipopolysaccharide (LPS), and defects in Nod2 have been linked to several diseases including Blau syndrome, Crohns's disease, and ulcerative colitis. Knock-out animals has been shown to have dramatically altered responses to bacterial pathogens in the gut. Nod2 binds to the receptor interacting kinase 1 protein via CARD-CARD interaction and induces NF-kappaB and IKK-gamma. The NOD-15 monoclonal antibody recognizes the human Nod2 protein and has been shown to be useful for Western blotting. The NOD-15 antibody does not cross-react with human Nod1.
Catalogue number: 625801
Hosts: Mouse
Applications: Western Blot
Size: 25 microg
Clone: NOD-15
Gene: 64127
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Recombinant human NOD2
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Caspase recruitment domain-containing protein 15, CARD15, inflammatory bowel disease protein 1
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