Purified anti-p53

Cat no: 645701

Supplier: BioLegend

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Description
Additional Information

p53 is a 53 kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when activated and can be upregulated by genotoxic or other cellular stresses. p53 is modified by phosphorylation, acetylation, ribosylation, ubiquitination, and sumoylation; ubiquination targets p53 for degradation via mdm2. This protein interacts with a variety of proteins including mdm2, mdmx, topoisomerase I, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, and HDAC1-3. Mutant p53 associates with p63 and p73.

Catalogue number:	645701
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	DO-1
Gene:	7157
Dilutions:	Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 - 1 microg per ml antibody for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	P53 N-terminal linear epitope aa 20-25
Isotype:	Mouse IgG2a
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Tumor protein p53 (TP53)