Purified anti-p63 (TA)

p63 (TA) is a member of the p53 family. This protein has multiple isoforms TA p63-alpha, -beta, -gamma, and deltaN p63-alpha, -beta, -gamma. The molecular weight of the TA p63 isoforms alpha=77 kD, beta=62 kD, and gamma=56 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, epithelial stem cell regeneration; deltaN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 deltaN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation This protein interacts with p53, p73, and the various p63 TA- and deltaN isoforms. The Poly6189 antibody recognizes human p63 TA isoforms and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

618901

Size

50 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6189

Antigen

Modified peptide

Gene Id

8626

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

p63, Isoforms TA p63-alpha, -beta, -gamma, deltaN p63-alpha, -beta, -gamma

Regulatory Status

RUO