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Purified anti-RORgammat

Purified anti-RORgammat

Cat no: 654301

Supplier: BioLegend
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RORgamma (Retinoid-related orphan receptor gamma) belongs to the nuclear hormone receptor family, NR1 subfamily. It contains one nuclear receptor DNA-binding domain. RORgamma has two isoforms: gamma1 and gamma2 (also referred to as RORgammat). RORgammat differs from the RORgamma1 isoform in that it lacks the amino terminus of RORgamma1. RORgamma1 contains 516 amino acids, and RORgammat contains 495 amino acids. RORgamma1 has a molecular weight of approximately 58 kD. RORgamma1 is highly expressed in thymus, kidney, liver, muscle, and brown fat but not in white fat tissue. RORgammat is specifically expressed in only two cell populations, DP thymocytes and lymphoid tissue inducers (LTi). RORgamma plays a critical role in controlling apoptosis during thymopoiesis and T cell homeostasis. RORgamma is said to regulate the TCRalpha repertoire by virtue of its positive regulatory role on Bcl-x expression. RORgamma is essential for lymph node and Peyer's patch development.
Catalogue number: 654301
Reactivities: Mouse
Hosts: Mouse
Applications: Western Blot
Size: 25 microg
Clone: 2F7-2
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partial mouse RORgammat recombinant protein
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: RORc, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma
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