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Purified anti-RUNX3

Purified anti-RUNX3

Cat no: 653601

Supplier: BioLegend
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RUNX3 belongs to the runt-domain family of transcription factors that regulates gene expression in major developmental pathways, such as T-cell differentiation and neurogenesis. RUNX3 is epigenetically silenced in many types of cancers. In gastric cancer, RUNX3 has been frequently reported to be inactivated by gene silencing or protein mislocalization. The oncoprotein SRC phosphorylates RUNX3 at multiple tyrosine residues, resulting in cytoplasmic mislocalization of RUNX3. RUNX3 is regulated by the TGF-B/Smad pathway, and induces apoptosis or cell cycle arrest of gastric cancer cells through upregulating expression of p21 and Bim. The loss of RUNX3 function in T-cells cause suppression of Treg function and formation of colitis tumor. These findings suggest an important role of RUNX3 in tumor suppression.
Catalogue number: 653601
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 25 microg
Clone: 9F4A17
Gene: 864
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.1-0.5 microg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partial human RUNX3 recombinant protein (194-304 aa).
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Runt-related transcription factor 3, Polyomavirus enhancer-binding protein 2 alpha C subunit (PEBP2 alpha C), Acute myeloid leukemia 2 (AML2)
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