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Purified anti-Sp1

Purified anti-Sp1

Cat no: 624702

Supplier: BioLegend
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The sequence-specific transcription factor Sp1 binds GC box sequences in the promoters of a variety of genes. The 97 kD Sp1 transcription factor contains two zinc finger domains that determine sequence specificity of binding to the 5'-GGGGCGGGGC-3'. This transcription factor regulates nucleoside, nucleotide and nucleic acid metabolism and many other "housekeeping" genes. Sp1 can be modified by phosphorylation by the upstream kinase ERK1 and has been shown to interact with a large number of proteins. The transcriptional activity of Sp1 has been shown to be disrupted in early Huntington's disease. The Poly6247 antibody recognizes human, mouse, and rat Sp1 and has been shown to be useful for Western blotting.
Catalogue number: 624702
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 500 microl
Clone: Poly6247
Gene: 6667
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 25 microl per 5 ml antibody dilution buffer for each mini-gel. For IHC, use a 1:50 dilution of antibody for staining. Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. DO NOT FREEZE.
Antigen: Peptide mapping to internal domain of human Sp1
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Transcription factor Sp1, SP1
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