Purified anti-Survivin

Survivin (also known as baculoviral IAP repeat-containing protein (BIRC5)) is a member of the IAP family containing a BIR domain. This protein has two reported isoforms alpha and beta, with reported molecular weights of approximately 16.5 kD and 18.6 kD, respectively. Survivin can form dimers and is distributed at the microtubules of the mitotic spindle. Survivin plays a possible role in neoplasia and is expressed in embryonic tissues and the majority of human cancers, but not in most normal adult tissues. Survivin may counteract default induction of apoptosis in G2/M phase, and inhibits caspase-3 and caspase-7 activation. Survivin is downregulated by p53 and stabilized by phosphorylation. Survivin is phosphorylated by cdc2. Survivin has been shown to interact with tubulin and HBXIP. The Poly6147 antibody recognizes the C-terminal region of human survivin and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

614702

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6147

Antigen

Recombinant (partial), C-terminal

Gene Id

332

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Baculoviral IAP repeat-containing 5 (BIRC5)

Regulatory Status

RUO