Purified anti-T-bet

Cat no: 644802

Supplier: BioLegend

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Description
Additional Information

T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-gamma. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12.

Catalogue number:	644802
Reactivities:	Human, Mouse
Hosts:	Mouse
Applications:	Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Size:	100 microg
Clone:	4B10
Gene:	30009
Dilutions:	Each lot of this antibody is quality control tested by Western blotting and intracelluar immunofluorescent staining with flow cytometric analysis. For Western blotting, the suggested use is 1 to 2 ug per ml. For immunofluorescent staining, the suggested use of this reagent is 1.0 microg per million cells in a staining volume of 100 microl. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	T box expressed in T cells, T box 21, TBLYM