Purified anti-TIF1beta (KAP-1, TRIM28)

Cat no: 619302

Supplier: BioLegend

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Description
Additional Information

TIFbeta (transcription intermediary factor 1-beta) is an 88 kD member of the tripartite motif family. This protein contains three zinc binding domains, a RING domain, a B-box type 1 and type 2 domain, and a coiled-coil region. TIFbeta is found in the nucleus and associates with specific chromatin regions. This protein forms a complex with KRAB-domain transcription factors and recruits setdbl to histone 3 to increase KRAB-mediated transcriptional repression. TIF1beta has been reported to interact with setdbl and cbx3 proteins. Studies using knockout mice reveal the important function of TIF1beta in regulating genomic imprinting, T cell activation, and T cell tolerance.

Catalogue number:	619302
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100 microg
Clone:	20A1
Gene:	10155
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store at 4C.
Concentration:	0.5 mg/ml
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Transcription intermediary factor 1-beta, KRAB-associated protein