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Purified anti-TRIM25

Purified anti-TRIM25

Cat no: 647602

Supplier: BioLegend
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TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family, and functions as a ubiquitin ligase. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. The presence of potential DNA binding and dimerization transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
Catalogue number: 647602
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100 microl
Clone: Poly6476
Gene: 7706
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this antibody: use 5 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Synthetic peptide
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: tripartite motif protein 25, estrogen responsive finger protein
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