Purified anti-TSC2 Phospho (Ser664)

Cat no: 635901

Supplier: BioLegend

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Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-bindingprotein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664.

Catalogue number:	635901
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry
Size:	25 microl
Clone:	Poly6359
Gene:	7249
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. For IHC, use a 1:50 dilution of antibody for staining. Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended.
Storage buffer:	Upon receipt, store frozen at -20C.
Antigen:	Modified peptide
Isotype:	Rabbit Polyclonal
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	-20 C
Alternative names:	Tuberin, Tuberous sclerosis 2 protein, TSC4

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Purified anti-TSC2 Phospho (Ser664)

Cat no: 635901

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