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Purified anti-UCP2

Purified anti-UCP2

Cat no: 615901

Supplier: BioLegend
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UCP2 also known as mitochondrial uncoupling protein 2 is a 33 kD member of the mitochondrial anion carrier protein family. This protein is expressed in the mitochondria and is highly expressed in brain, kidney, liver, brown adipose tissue, heart, and muscle tisuue. UCP2 facilitates transfer of anions from the inner to the outer mitochondrial membrane and the return of protons from the outer to the inner mitochondrial membrane. This reduces mitochondrial membrane potential and induces mitochondrial "leak" in which oxidative phosphorylation is separated from ATP synthesis with energy dissipated as heat. UPC2 function has been linked to obesity and hyperinsulinemia and has been shown to be decreased by glucose and leptin in human islet cells. UCP2 has also been shown to interact with 14-3-3 beta and gamma isoforms. The Poly6159 antibody recognizes the N-terminal region of the human UCP2 protein and has been shown to be useful for Western blotting.
Catalogue number: 615901
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50 microl
Clone: Poly6159
Gene: 7351
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Recombinant (partial), N-terminal
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: Mitochondrial uncoupling protein 2, Uncoupling protein 2, UCP 2
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