Purified anti-UCP2

UCP2 also known as mitochondrial uncoupling protein 2 is a 33 kD member of the mitochondrial anion carrier protein family. This protein is expressed in the mitochondria and is highly expressed in brain, kidney, liver, brown adipose tissue, heart, and muscle tisuue. UCP2 facilitates transfer of anions from the inner to the outer mitochondrial membrane and the return of protons from the outer to the inner mitochondrial membrane. This reduces mitochondrial membrane potential and induces mitochondrial "leak" in which oxidative phosphorylation is separated from ATP synthesis with energy dissipated as heat. UPC2 function has been linked to obesity and hyperinsulinemia and has been shown to be decreased by glucose and leptin in human islet cells. UCP2 has also been shown to interact with 14-3-3 beta and gamma isoforms. The Poly6159 antibody recognizes the N-terminal region of the human UCP2 protein and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

615902

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6159

Antigen

Recombinant (partial), N-terminal

Gene Id

7351

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Mitochondrial uncoupling protein 2, Uncoupling protein 2, UCP 2

Regulatory Status

RUO