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Purified anti-ZBP-1

Purified anti-ZBP-1

Cat no: 651602

Supplier: BioLegend
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Z-DNA binding protein 1 (ZBP-1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RAN. Vertebrate ZBPs are induced by immunostimulation and are involved in host defense mechanisms. ZBP-1 initiates an innate immune response by binding to foreign DNA in the cytosol. ZBP-1 mediates activation of the innate immune system by facilitating DNA-mediated induction of type-1 IFN and expression of other related genes. Human ZBP-1 is most prominently expressed in lymphatic tissues. Besides its function in immunoresponse, it is up-regulated in mouse tumor stromal cells and is speculated to play a role in host defense again tumors.
Catalogue number: 651602
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100 microg
Clone: RonoB19
Gene: 81030
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Recombinant human ZBP-1, antibody recognizing Zbeta domain
Isotype: Rat IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Z-DNA binding protein 1, Tumor stroma and activated macrophage protein DLM-1, DNA-dependent activator of interferon regulatory factors
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