RAB24 belongs to the small GTPase superfamily. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of RAB24 remains unknown. RAB24 is distributed in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures, and this subcellular distribution pattern of RAB24 may indicate its involvement in autophagy-related processes. RAB24 presents unusual characteristics, including low intrinsic GTPase activity, and is inefficiently prenylated when compared with other Rab proteins. Also suggested that RAB24 might play a unique role in the degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope.
Source:
Recombinant corresponding to aa1-203 from human RAB24, fused to His-tag at N-terminal expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGSHMSGQRV DVKVVMLGKE YVGKTSLVER YVHDRFLVGP YQNTIGAAFV AKVMSVGDRT VTLGIWDTAG SERYEAMSRI YYRGAKAAIV CYDLTDSSSF ERAKFWVKEL RSLEEGCQIY LCGTKSDLLE EDRRRRRVDF HDVQDYADNI KAQLFETSSK TGQSVDELFQ KVAEDYVSVA AFQVMTEDKG VDLGQKPNPY FYSCCHH
Molecular Weight:
~25.7kD (MALDI-TOF)
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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