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RAB4A, Recombinant, Human, aa1-218, His-tag (Member RAS Oncogene Family, Oncogene RAB4)

Cat no: R0007-10A

RAB4A, Recombinant, Human, aa1-218, His-tag (Member RAS Oncogene Family, Oncogene RAB4)

RAB4A belongs to the small GTPase superfamily. RAB4A has been shown to interact with STX4, RAB11FIP1, RABEP1, CD2AP and KIF3B. Rab4 is also involved in the translocation of glucose transporter (Glu4) in adipocytes in response to insulin. Overexpression of Rab4 causes a redistribution of receptors on plasma membrane versus endocytic compartments. Purified by using conventional chromatography.\n\nSource:\nRecombinant corresponding to aa1-218 of human RAB4A, fused to His-tag at N-terminal, expressed in E.coli. \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG\nENVEEAFVQC ARKILNKIES GELDPERMGS GIQYGDAALR QLRSPRRAQA PNAQECGC\n\nMolecular Weight: \n~26.5kD (238aa), confirmed by MALDI-TOF\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

R0007-10A

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH8, 0.1M sodium chloride, 1mM DTT, 20% glycerol.

Purity

~90% (SDS-PAGE)

References

Li L. et al. (2001) J Biol Chem. 276:5265-73. Lindsay AJ.. et al. (2002) J Biol Chem. 277:12190-9.

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