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Rabbit Anti-ACACA monoclonal antibody, clone TU64-19

Cat no: DCABH-204

Rabbit Anti-ACACA monoclonal antibody, clone TU64-19

Rabbit Anti-ACACA monoclonal antibody for WB, IHC. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC? (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC? (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC? is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme's short-term regulatory mechanism. The gene encoding ACC? maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC? is homologous to that of the ACC?, except for an additional peptide of about 150 amino acids at the N-terminus.

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SPECIFICATIONS

Catalog Number

DCABH-204

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TU64-19

Target

ACACA

Gene Id

10533

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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