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Rabbit Anti-AMPK alpha 2 monoclonal antibody, clone KK19-20

Cat no: DCABH-2146

Rabbit Anti-AMPK alpha 2 monoclonal antibody, clone KK19-20

Rabbit Anti-AMPK alpha 2 monoclonal antibody for WB, ICC/IF, IHC. Five-prime-AMP-activated protein kinase, known as AMPK, is a heterotrimeric complex that comprises of a catalytic ? subunit, and regulatory ? and ?. AMPK protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP via a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase (AMPKK), and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPK?1 gene maps to chromosome 5p12 and encodes a 548 amino acid protein. The major regulatory site phosphorylated by AMPKK on AMPK? has been identified as Thr 172 within the activation loop between the DFG and APE motifs of the alpha-subunits.

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SPECIFICATIONS

Catalog Number

DCABH-2146

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

KK19-20

Target

AMPK alpha 2

Gene Id

898

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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