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Rabbit Anti-ANGPT1 monoclonal antibody, clone TO78-13

Cat no: DCABH-7704

Rabbit Anti-ANGPT1 monoclonal antibody, clone TO78-13

Rabbit Anti-ANGPT1 monoclonal antibody for WB. Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling.

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SPECIFICATIONS

Catalog Number

DCABH-7704

Hosts

Rabbit

Reactivities

Hum, Rat

Conjugates

Unconj

Clone

TO78-13

Target

ANGPT1

Gene Id

915

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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