Rabbit Anti-ATPase monoclonal antibody for WB, ICC/IF, IHC, FC. The ubiquitously expressed sodium/potassium-ATPase (Na/K-ATPase) exists as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Naions and two Kions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na/K-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, ?, ? and ?, comprise the Na/K-ATPase oligomer. The ? subunit contains the binding sites for ATP and the cations; the glycosylated ? subunit ensures correct folding and membrane insertion of the ? subunits. The small ? subunit co-localizes with the ? subunit in nephron segments, where it increases the affinity of Na/K-ATPase for ATP. The ? subunit, but not the ? subunit, is essential for normal activity of Na/K-ATPase.
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