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Rabbit Anti-Axin2 monoclonal antibody, clone KN22-41

Rabbit Anti-Axin2 monoclonal antibody, clone KN22-41

Cat no: DCABH-198

Supplier: Creative Diagnostics
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Rabbit Anti-Axin2 monoclonal antibody for WB, ICC/IF, IHC. b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.
Catalogue number: DCABH-198
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: KN22-41
Gene: 2247
Target: Axin2
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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