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Rabbit Anti-Beta-Catenin monoclonal antibody, clone TB41-15

Cat no: CABT-BL8493

Rabbit Anti-Beta-Catenin monoclonal antibody, clone TB41-15

Rabbit Anti-Beta-Catenin monoclonal antibody for WB, ICC, IHC, IP. ?-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. GSK-3? destabilizes ?-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of ?-catenin protein levels and have been found in many tumor cell lines.

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SPECIFICATIONS

Catalog Number

CABT-BL8493

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TB41-15

Target

Beta-Catenin

Gene Id

9759

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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