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Rabbit Anti-Beta-Catenin monoclonal antibody, clone TB41-15

Rabbit Anti-Beta-Catenin monoclonal antibody, clone TB41-15

Cat no: CABT-BL8493

Supplier: Creative Diagnostics
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Rabbit Anti-Beta-Catenin monoclonal antibody for WB, ICC, IHC, IP. ?-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. GSK-3? destabilizes ?-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of ?-catenin protein levels and have been found in many tumor cell lines.
Catalogue number: CABT-BL8493
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TB41-15
Gene: 9759
Target: Beta-Catenin
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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