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Rabbit Anti-CD86 monoclonal antibody, clone TK31-11

Rabbit Anti-CD86 monoclonal antibody, clone TK31-11

Cat no: DCABH-9113

Supplier: Creative Diagnostics
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Rabbit Anti-CD86 monoclonal antibody for WB, ICC/IF, IHC, IP, FC. T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins B7-1 (CD80) and B7-2 (CD86) expressed on antigen presenting cells bind the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28, and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
Catalogue number: DCABH-9113
Reactivities: Human, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TK31-11
Gene: 5241
Target: CD86
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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