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Rabbit Anti-CDKN1B monoclonal antibody, clone TV48-15

Cat no: CABT-BL8468

Rabbit Anti-CDKN1B monoclonal antibody, clone TV48-15

Rabbit Anti-CDKN1B monoclonal antibody for WB, ICC/IF, IHC, IP, FC. Cell cycle progression is regulated by a series of cyclin-dependent kinases consisting of catalytic subunits, designated Cdks, as well as activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has recently been described that function as "mitotic inhibitors." These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16; and a more recently described p16-related inhibitor designated p15. A p21-related protein, p27, has been described as a negative regulator of G1 progression and speculated to function as a possible mediator of TGF?-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and, to a lesser extent, with cyclin E and Cdk2.

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SPECIFICATIONS

Catalog Number

CABT-BL8468

Hosts

Rabbit

Reactivities

Hum, Rat

Conjugates

Unconj

Clone

TV48-15

Target

CDKN1B

Gene Id

10618

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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