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Rabbit Anti-CDKN1B monoclonal antibody, clone TV48-15

Rabbit Anti-CDKN1B monoclonal antibody, clone TV48-15

Cat no: CABT-BL8468

Supplier: Creative Diagnostics
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Rabbit Anti-CDKN1B monoclonal antibody for WB, ICC/IF, IHC, IP, FC. Cell cycle progression is regulated by a series of cyclin-dependent kinases consisting of catalytic subunits, designated Cdks, as well as activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has recently been described that function as "mitotic inhibitors." These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16; and a more recently described p16-related inhibitor designated p15. A p21-related protein, p27, has been described as a negative regulator of G1 progression and speculated to function as a possible mediator of TGF?-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and, to a lesser extent, with cyclin E and Cdk2.
Catalogue number: CABT-BL8468
Reactivities: Human, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TV48-15
Gene: 10618
Target: CDKN1B
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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