Rabbit Anti-CEBPB monoclonal antibody for WB, ICC/IF, IP, FC. CCAAT-enhancer binding proteins (C/EBP) are basic region/leucine zipper (bZIP) transcription factors selectively expressed during the differentiation of liver, adipose tissue, blood cells and the endocrine pancreas. C/EBP ? is a member of the C/EBP transcription factor family. The C/EBP ? gene encodes several isoforms containing truncated transcription activation domains due to the alternative translational initiation at multipe AUG start sites. C/EBP ? is also known as interleukin 6-dependent DNA-binding protein (IL6DBP), liver activator protein (LAP) or liver-enriched transcriptional activator protein transcription factor 5 (TCF5). C/EBP ? contributes to the regulation of the acute phase response in hepatocytes. Stat3 has an important function in IL-6-mediated transcription of the C/EBP ? gene that has direct implication for acute phase response in liver cells.The C/EBP ? form requires phosphorylation for its DNA binding ability, and increase binding of C/EBP ? isoforms during acute-phase reaction occurs through its upregulation and structural modification.
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