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Rabbit Anti-CPT2 monoclonal antibody, clone TO17-81

Cat no: DCABH-7092

Rabbit Anti-CPT2 monoclonal antibody, clone TO17-81

Rabbit Anti-CPT2 monoclonal antibody for WB, ICC/IF, IHC. The mitochondrial ?-oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase (CPT) I (outer membrane and detergent labile) and II (inner membrane and detergent stable), together with carnitine carrier. CPTI catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation. Two types of CPTI are known, the liver (CPTIA) and muscle (CPTIB) isoforms. The muscle type protein is specially expressed in heart and skeletal muscle. Membrane-bound CPTI, but not CPTII, is inhibited reversibly by malonyl-coenzyme A (CoA). Unlike CPTII, CPTI requires membrane integrity for catalytic function. In addition, glutamic acid 3 and histidine 5 are necessary for malonyl CoA inhibition and binding to liver CPTI, but not for catalytic activity.

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SPECIFICATIONS

Catalog Number

DCABH-7092

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

TO17-81

Target

CPT2

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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