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Rabbit Anti-ERCC1 monoclonal antibody, clone KN21-18

Cat no: CABT-L911

Rabbit Anti-ERCC1 monoclonal antibody, clone KN21-18

Rabbit Anti-ERCC1 monoclonal antibody for WB, ICC/IF, IHC. Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endo-nuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.

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SPECIFICATIONS

Catalog Number

CABT-L911

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Unconj

Clone

KN21-18

Target

ERCC1

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at +4В°C after thawing. Aliquot store at -20В°C or -80В°C. Avoid repeated freeze / thaw cycles.

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