Rabbit Anti-FNTB monoclonal antibody for WB, ICC/IF. Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical ? and ? subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The ? subunit, which is known as FT?, CAAX farnesyltransferase subunit ?, or Ras proteins prenyltransferase subunit ?, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The ? subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.